SPM supplements built on the science of resolution Powered by patented Lipinova® SPM technology Formulated to support recovery through inflammation resolution

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Sports ProResolve bottle — 90 softgels

ProResolving What Matters

Science-backed SPM supplements designed to support your body’s natural inflammation resolution process.

Sports ProResolve is specifically formulated to support the active resolution of inflammation following physical activity, helping promote the body’s natural recovery process and support post-exercise comfort.

Unlike a conventional fish oil supplement, Sports ProResolve is formulated with Lipinova® SPM, a unique and patented ingredient standardized in SPM levels: 18-HEPE, 17-HDHA, and 14-HDHA.

Sports ProResolve is designed to help you recover faster, optimize your performance, and give it your all, time and time again.

Your body already knows how to heal.
Sometimes, it simply needs the right support.

Inflammation is protection, not the problem.

Inflammation is a natural and necessary response that helps your body protect and repair itself. The problem begins when inflammation doesn’t properly resolve and stays active for too long.

The molecules behind this process have a name: SPM.

SPM are naturally produced by your body to help complete the inflammatory response. Think of them as the signal that helps your body move from inflammation to resolution and recovery.

Not all SPM ingredients are Lipinova® SPM.

Lipinova® SPM is a patented SPM ingredient backed by clinical research and developed in collaboration with Dr. Charles Serhan, who pioneered the discovery of SPM and chairs our Scientific Advisory Board.

Dr. Serhan discovered that inflammation doesn’t simply fade away.

Research revealed that the body has an active process designed to bring inflammation to an end. This discovery changed our understanding of how the body returns to balance.

Lipinova® SPM brings this science into a tangible solution.

Lipinova® SPM provides concentrated SPM and their precursors, designed to support your body’s natural resolution process.

  1. Inflammation is protection, not the problem.

    A natural response that protects and repairs. The problem begins when it doesn’t resolve and stays active for too long.

  2. Dr. Serhan discovered that inflammation doesn’t simply fade away.

    Research revealed the body has an active process to bring it to an end. That changed how we understand recovery.

  3. The molecules behind this process have a name: SPM.

    Your body produces them to complete the inflammatory response: they are the signal that moves you from inflammation to recovery.

  4. Lipinova® SPM brings this science into a tangible solution.

    Provides concentrated SPM and their precursors, designed to support your body’s natural resolution process.

  5. Not all SPM ingredients are Lipinova® SPM.

    Lipinova® is backed by clinical research and developed with Dr. Charles Serhan, who pioneered the discovery of SPM and chairs our Scientific Advisory Board.

Lipinova® is the patented ingredient
behind every ProResolve product.

Developed by Solutex GC, Lipinova® is a highly purified and standardized SPM fraction. Every batch is manufactured to deliver a precise and consistent composition of Specialized Pro-Resolving Mediators (SPM). Delivered in a highly bioavailable triglyceride form, Lipinova® provides targeted support to help restore the body’s natural balance.

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Why people trust Lipinova®?

Developed by SPM pioneers.

Lipinova® is a patented ingredient developed by Solutex GC, pioneers in the discovery, development, and production of SPM.

Standardized quality.

Every batch is produced through a patented purification process, ensuring the same precise, standardized composition in every dose.

Backed by Science.

Lipinova® has been studied in clinical and preclinical research, showing improvements in quality of life and reduction in pain within weeks.

Möller I et al. Annals of the Rheumatic Diseases. 2024;83:2215.
Möller I et al. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2026;210:102758.
Distefano A et al. Pharmaceuticals. 2024;17(8):1066.

Supports your body’s natural biology.

Supports your body’s natural inflammation-resolution process without suppressing the immune system.

Schaller MS et al. J Am Heart Assoc. 2020;9(15):e016113.

Non-immunosuppressive & no recorded side effects.

Schaller MS et al. J Am Heart Assoc. 2020;9(15):e016113.

Naturally derived.

Derived from highly purified marine oils, never synthetic compounds.

Advancing science through collaboration

At ProResolve, we believe the best scientific breakthroughs happen when knowledge is shared.

That's why we drive SSPAAIN, a data space we've built to bring together researchers, healthcare institutions, and industry, focused on patient data from osteoarthritis and sports recovery to accelerate innovation in inflammation, pain, and mobility.

By leading this collaborative research effort, we help advance the science that will shape better health solutions for the future.

Is your team working on osteoarthritis or sports recovery research?

If you'd like to contribute data, access existing datasets, or explore how a shared data space like SSPAAIN could support your work, get in touch with us.

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Frequently Asked Questions

A conventional omega-3 supplement provides the raw building blocks, but your body still has to convert them into the compounds involved in resolving inflammation, and not everyone does that efficiently. Lipinova® is formulated to support that specific pathway directly, rather than supplying general omega-3 and hoping the rest follows.

NSAIDs work by reducing or blocking the inflammatory response to relieve symptoms. Lipinova® takes a different approach: instead of suppressing inflammation, it supports the body’s own resolution process, the mechanism that actually completes healing and restores balance.

Yes. The clinical research behind ProResolve has been carried out with Lipinova® itself, not with SPM in general. Many products in this category reference broad research on the ingredient class; ours evaluates the exact formula in the bottle.

Lipinova® is formulated with naturally derived ingredients and is generally well tolerated. As with any food supplement, we recommend consulting your healthcare professional before use if you are pregnant, breastfeeding, taking medication or have an existing medical condition.

An SPM supplement delivers Specialized Pro-Resolving Mediators directly, the molecules your body would otherwise have to produce itself from omega-3 fatty acids. Standard fish oil provides the raw EPA and DHA, and your body still has to do the converting.

Clinical research with Lipinova® has shown improvements in quality of life and reductions in discomfort within one to four weeks, depending on the individual and their level of physical stress.

Möller I et al. Annals of the Rheumatic Diseases. 2024;83:2215.
Möller I et al. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2026;210:102758.

Check for three things: standardization of SPM (18-HEPE, 17-HDHA, and 14-HDHA), clinical research conducted on the specific branded ingredient rather than on SPM in general, and independent batch testing.

Lipinova®, the leading branded SPM ingredient, meets all three criteria, making it the best choice for scientifically backed SPM supplementation. Sports ProResolve, powered by Lipinova®, is also Informed Sport certified, providing an added level of quality assurance for athletes.

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